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A sedating effect
Inhalation of α-pinene (which produced measurable concentrations in the brain) produced an anxiolytic effect, although higher brain concentrations were associated with an excitatory effect.I did not find any studies that looked directly at the anticonvulsant activity of α-pinene, but several essential oils that have α-pinene as a component reduced seizures.
Myrcene and α-pinene increased GABA receptor activity in cell experiments.
The effect of α-pinene in neurons was fully blocked by flumazenil.
Many of these plants have had traditional medicinal uses for hundreds of years.
Some of these traditional medicinal uses include calming or sleep-inducing effects (basically the things that a sedative would be used for).
I am lumping 5 of the terpenes together, because they seem to act in the same way.
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All have similar activities in rodents and all have a similar mechanism of action by working through the GABA system.GABA is the main inhibitory neurotransmitter in the brain and it exerts its effects through reducing neuronal excitability.There are two receptors for GABA – the GABA receptors .This article will focus on the effects of terpenes taken internally.I will focus primarily on animal and mechanistic studies. There is actually very little research on isolated terpenes in humans.However, I will be covering what research is available in a future article.We need to be a little more specific when we say that a terpene has sedative or calming effects.In fact, it was difficult to even find a proper review on sedative effects of terpenes in the scientific literature.So I made this guide on the sedative and anxiolytic (anti-anxiety) effects of terpenes to understand the science behind what they do and how they work.When I hear these descriptions, it sounds to me like they are sedatives.Unfortunately there is often little detail on the science behind these claims.